NTRK2

This study employed a bioinformatics approach to identify differentially expressed genes (DEGs) in various types of colorectal adenomas (tubular, tubulovillous, villous) compared to normal tissues. Gene expression data analysis revealed 1,024 common DEGs, with COL1A2 and CXCL8 identified as hub genes. Specific genes for each adenoma type were also discovered. RT-qPCR validation and ROC analysis confirmed the discriminative potential of CXCL8 and COL1A2 in distinguishing adenomatous/cancerous tissues from normal mucosa. These findings offer valuable insights into adenoma biology and suggest potential targets for colorectal cancer prevention and treatment.

This study investigated oncogenic fusions in 11 unclassified pulmonary spindle cell tumors, aggressive neoplasms with limited treatment options. Using anchored multiplex PCR-based targeted RNA sequencing, researchers identified ALK gene fusions in two patients (18.2%), specifically PPFIBP1::ALK and SYCL3::ALK. Both tumors also exhibited positive ALK immunohistochemical staining, despite showing morphological heterogeneity. These findings expand the molecular spectrum of these rare tumors and highlight the importance of detecting ALK fusions, including those with uncommon partners.